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| High-Yield CD Markers | ||
|---|---|---|
| CD Marker | Cell / Function | Clinical Relevance |
| CD1a | Langerhans cells | Seen in Langerhans cell histiocytosis (Birbeck granules) |
| CD3 | All T cells (part of TCR complex) | PAN-T cell marker (e.g. T-ALL) |
| CD4 | Helper T cells | HIV targets CD4+ cells |
| CD5 | T cells some B cells | Expressed in CLL/SLL (B-cell tumor with aberrant CD5) |
| CD8 | Cytotoxic T cells | Viral immunity, MHC I restricted |
| CD10 | Pre-B cells germinal center B cells | ALL Follicular lymphoma |
| CD11b | Myeloid, monocytes | Adhesion and migration ↑ in myelomonocytic leukemias |
| CD13 | Myeloid lineage | Positive in AML (granulocytic marker) |
| CD14 | Macrophages | Binds LPS (endotoxin receptor) |
| CD15 | Granulocytes | Also positive in Hodgkin lymphoma |
| CD16 | NK cells, neutrophils | Fc receptor for ADCC |
| CD18 | Integrin (leukocytes) | Deficient in LAD type 1 (leukocyte adhesion deficiency) |
| CD19 | B cells | Used in B cell lineage cancers (e.g. B-ALL) |
| CD20 | B cells (mature) | Target of rituximab (e.g. lymphomas) |
| CD21 | B cells, EBV receptor | EBV entry point (mono, Burkitt) |
| CD23 | Mature B cells | CLL (CD5+ CD23+) Mantle cell (CD5+ CD23−) |
| CD25 | Tregs activated T cells | IL-2 receptor dysregulation in autoimmunity |
| CD28 | T cells | Binds B7 for costimulation |
| CD30 | Activated B & T cells | Positive in Reed-Sternberg cells (Hodgkin lymphoma) |
| CD31 | Endothelial cells (PECAM-1) | Marker for angiosarcoma including hepatic angiosarcoma |
| CD33 | Myeloid precursor cells | Target of gemtuzumab (AML therapy) |
| CD34 | Stem cells Endothelial precursors | Used in stem cell markers |
| CD34 | Hematopoietic stem cells | Stem cell marker for bone marrow transplants |
| CD38 | Plasma cells | Multiple myeloma marker |
| CD55/CD59 | Complement regulatory proteins | Deficient in PNH |
| CD56 | NK cells | Specific NK marker (CD16+/CD56+) |
| CD79a | B cells | Present in most B-cell neoplasms |
| CD117 (c-Kit) | Stem cells, mast cells | Seen in GIST (gastrointestinal stromal tumors) |
| CD138 | Plasma cells | Multiple myeloma marker |
| CD95 (Fas) | Death receptor (apoptosis) | Involved in activation-induced cell death Deficient in ALPS (autoimmune lymphoproliferative syndrome) |