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Disease-Associated Autoantibodies
Condition Autoantibody Condition Autoantibody
Antiphospholipid syndrome
  • Anti-β2 glycoprotein
 Autoimmune hepatitis
  • Anti-smooth muscle
Bullous pemphigoid
  • Antihemidesmosome
 Celiac disease
  • IgA anti-endomysial
  • IgA anti-TTG
Diffuse systemic sclerosis
  • Anti-topoisomerase I
 Drug-induced lupus
  • Antihistone
Myasthenia gravis
  • Anti-ACh receptor
 Goodpasture syndrome
  • Anti-GBM
Graves disease
  • Anti-TSH receptor
 Hashimoto thyroiditis
  • Antimicrosomal
  • Anti-TPO
  • Antithyroglobulin
Lambert-Eaton syndrome
  • Anti-VGCC
 Limited systemic sclerosis
  • Anticentromere
Microscopic polyangiitis
  • p-ANCA
  • MPO-ANCA
 Mixed connective tissue disease
  • Anti-U1 RNP
SLE (screen)
  • ANA
 Pemphigus vulgaris
  • Antidesmoglein
Pernicious anemia
  • Anti-intrinsic factor
 Polymyositis / Dermatomyositis
  • Anti-SRP
  • Antihelicase (Mi-2)
Primary biliary cholangitis
  • Antimitochondrial
 SLE
  • Anticardiolipin
SLE (specific)
  • Anti-dsDNA
  • Anti-Smith
 Stiff person syndrome
  • Anti-GAD65
Sjögren syndrome
  • Anti-SSA
  • Anti-SSB
 Type 1 diabetes
  • Anti-GAD
  • Islet cell Ab
Autoimmune encephalitis
  • Anti-NMDA receptor
 Neuromyelitis optica
  • Anti-aquaporin-4
Rheumatoid arthritis
  • RF
  • Anti-CCP
 Paraneoplastic syndromes
  • Anti-Hu
  • Anti-Yo
  • Anti-Ri
Abbreviations: ACh = acetylcholine, ANA = antinuclear antibody, ANCA = antineutrophil cytoplasmic antibody, CCP = cyclic citrullinated peptide, GAD = glutamic acid decarboxylase, GBM = glomerular basement membrane, MPO = myeloperoxidase, RF = rheumatoid factor, SRP = signal recognition particle, TPO = thyroid peroxidase, TSH = thyroid-stimulating hormone, TTG = tissue transglutaminase, VGCC = voltage-gated calcium channel.